Neurons in Action
Tutorials and Simulations using NEURON

Versions

Version Release Date System Requirements Major Changes from Previous Version
2.1.5-betas February-November 2023
  • macOS 10.10 or newer, 64-bit only (ARM/x86)
  • Windows 10 or newer
    		•
    • Introduce new ARM version of NIA2/NEURON to support Apple Silicon Macs
    • Use custom NEURON 9-dev build for macOS arm
    • Upgrade to Electron 23
    • Update to Electron's built-in PDF viewer
    2.1.4 November 2021
  • macOS 10.9 or newer, 64-bit only (x86)
  • Windows 7 or newer
    		•
    • Fix Alpha Synapse panel bug in Phaseplane Tutorial on Windows version
    2.1.3 October 2021
  • macOS 10.9 or newer, 64-bit only (x86)
  • Windows 7 or newer
    		•
    • Multiple bug fixes from 2.1.1
    2.1.1 July 2021
  • macOS 10.9 or newer, 64-bit only (x86)
  • Windows 7 or newer
    		•
    • Repackaged using Electron 6
    • Drops Firefox as a dependency
    • User interface redesign
    • New launch process
    • Updated to NEURON 7.6.5
    • Requires XQuartz on macOS
    2.1.0 betas 2016-2021
    • NIA 2.1 beta versions provided to selected users for testing
    2.0.11 2015
    • Update for compatibility with Mac OSX 10.11
    2.0.4 2014
    • Available as download
    • Removed Mac Dock icon after simulation completed
    2.0.3 2011
    • Includes new text about recently approved therapy for Multiple Sclerosis linked from the Partial Demyelination Tutorial
    • Includes all recent patches for both Mac and Windows
    • New toolbar bookmark to "Patches/Support"
    2.0.2 2009
    (July Reprint)
    • Ohms Law equation corrected
    • HH Equation: in the text at the bottom of the link, m and h were exchanged
    • Myelin Tutorial/Page 86: added a third paragraph under "Description of the Panels and Windows..." as follows:

      "3. The parameters panels

      The Nodal and Myelinated Region Parameters panels are read-out only; you should not attempt to change the numbers in the fields as they will have no effect on the simulation. The values for capacitance, leakage, and channel density in the Myelinated Region panel will be calculated and displayed according to the number of myelin wraps."

    • Demyelin Tutorial/Page 93: replaced "segment" with "internode"
    • Kinetics Tutorial/Page 107: changed text to:

      "the probability of activation of any given Na channel, described by m, is now slightly lower"

    • Kinetics Tutorial/Page 108: the word "not" is in the wrong line! Add "not" to l.1 of para 2 and delete "not" from l.3 of para 2.
    2.0.1 2007
    • Runs out-of-the-box on Windows Vista
    • Windows Firefox users can now run NIA2 without experiencing conflicts between user and NIA2 preferences
    2.0 2007
    • New print edition
    • 9 new tutorials; 16 tutorials revised
    • New interface
    • Extensive additions to hyperlinked content
    • Sound added to action potential minimovies
    • Upgraded to NEURON 5.9
    1.5 2004
    • Added Minimovies: Under "For Instructors," a set of QuickTime movies is available showing the generation and propagation of action potentials and properties of postsynaptic potentials.
    • Information for using the movies in PowerPoint presentations is included.
    1.45 2004
    • Upgraded to Firefox: The tutorials, NEURON, and the browser Firefox are bundled together for an easy one-step drag and drop installation.
    • Upgraded to NEURON 5
    • Mac OS X support: For computers running Mac OS 10.3 and Windows, this package includes a Mac OS X native version of NEURON.
    • For Mac OS 9, 10.1 and 10.2, NIA 1.45 employs the Mozilla browser and a version of NEURON running in OS9/Classic.
    1.43 2003
    • Upgraded to NEURON 4.3
    • Added speed adjustment slider to the RunControl panel of all tutorials involving moving simulations.

      Important: In The Partial Demyelination Tutorial this bar must be kept at its fastest setting or the tutorial will not work as described.

    • Separation of Mac and PC files in the file structure
    1.01 2001
    • Mylenated Axon Tutorial:
      Under "Measure conduction velocity and determine how the degree of myelination affects velocity":
      Corrected sentence: "As you add wraps, the capacitance is reduced to 0.5 uF/cm^2 with one wrap, to 0.333 uF/cm^2 with two wraps, etc., since the net capacitance of capacitors in series is the recriprocal of the sum of their reciprocals."
    • Passive Axon Tutorial:
      Under "How does the length constant change with axon diameter?":
      "Run the simulation." The equations on the page linked to "twice as large" have been corrected.
    • Synaptic Integration Tutorial:
      Under "Generate EPSPs in the dendrites and observe where the spike initiates":
      In the linked text to "Why is it so steep?" the value "thousandfold" has been corrected to "hundredfold."
    1.0 2000 Original Version
    • Distributed as a Book/CD-ROM
    • NEURON 4.2
    • Netscape 4.7